摘要
目的探讨TopoⅡ及Ki-67在食管鳞癌的表达及其与肿瘤分化程度、淋巴结转移的关系。方法应用免疫组化检测75例食管鳞癌组织中TopoⅡ和Ki-67的表达情况。结果TopoⅡ和ki-67的表达与食管鳞癌的组织分化程度和淋巴结转移均有密切关系(P<0.05),并且TopoⅡ和ki-67阳性表达具有较强的一致性。结论检测TopoⅡ和ki-67的表达可作为判断食管鳞癌预后的重要指标。
Objective To discuss the expression of Topo II and Ki - 67 in esophageal sqauamous cell carcinoma and their relationship with the histodifferentiation grades and lymph node metastasis. Methods Immunohistochemistry was applied to study the expression. Results Topo Ⅱ and Ki - 67 were closely related to the histodifferentiation grades and lymph node metastasis of esophageal squamous cell carcinoma , and there existed a great consistence between the positive expression of Topo Ⅱ and Ki - 67. Conclusions The expression of Topo Ⅱ and Ki - 67 can be used as the important index in judging the prognosis of esophageal squamous cell carcinoma.
出处
《西南军医》
2008年第5期8-9,共2页
Journal of Military Surgeon in Southwest China
关键词
食管鳞癌
Top0Ⅱ
KI-67
免疫组化
esophageal squamous cell carcinoma Topo Ⅱ Ki - 67 immunohistochemistry
