泌尿生殖道解脲脲支原体、人支原体检测与耐药性分析

Detection and Drug Resistance Analysis of Ureaplasma urealyticum and Mycoplasma hominis of Urogenital Tract

目的了解解脲脲支原体(Uu)和人支原体(Mh)在绍兴地区泌尿生殖道感染中的检测及耐药情况。方法采用法国生物梅里埃公司的试剂盒进行Uu、Mh的检测和药敏试验。结果2678例疑似泌尿生殖道感染的患者,有980例支原体(My)培养阳性,阳性率为36.6%,其中Uu阳性763例占28.5%;Mh阳性116例占4.3%;Uu和Mh混合阳性101例占3.8%;药敏试验Uu和Mh对抗菌药物敏感性最高的是普那霉素(原始霉素)、交沙霉素、多西环素和四环素,对环丙沙星、氧氟沙星、红霉素、克拉霉素和阿奇霉素耐药率最高。结论临床上支原体感染的治疗应根据实验室的药敏结果选择合适的抗菌药物。

OBJECTIVE To find out the status about detection and drug resistance of Ureaplasma urealyticurn （Uu） and Mycoplasrna horninis （Mh） of urogenital tract infection in Shaoxing area of Zhejiang Province. METHODS The detections and drug sensitive tests of Uu and Mh adopting the reagent boxes produced by bioMerieux Company in France were made. RESULTS In 2678 samples of suspicious urogenital tract infection patients, 980 samples cultured of mycoplasma were positive, and the positive rate was 36.6%. Among these cases, 763 samples （28.5M） were Uu positive; 116 samples （4.3%） were Mh positive. In the drug sensitive test, Uu and Mh were most sensitive to PRI, JOS, DOX and TET. To CFLX, OFL, ERY, CM and AM, they had the highest level of drug resistance. CONCLUSIONS The clinical therapy of mycoplasma infection ought to choose the appropriate antibiotics based on the results of the drug sensitive test of the laboratory.