宫颈鳞癌组织中组织蛋白酶B、层粘连蛋白表达及其意义

Expression of Cathepsin B and Laminin Protein in Squamous Carcinoma of Cervix and Its Significance

目的探讨宫颈鳞癌组织中组织蛋白酶B(Cathepsin B,CB)、层粘连蛋白(Laminin,LN)表达情况,研究其与宫颈鳞癌浸润及转移的内在关系。方法采用免疫组化SP法检测60例宫颈鳞癌组织中CB、层粘连蛋白的表达。结果CB高表达与宫颈鳞癌淋巴结转移、浸润深度关系密切(P<0.05);LN表达下调与宫颈鳞癌淋巴结转移、浸润深度关系密切(P<0.05);宫颈鳞癌中CB和LN蛋白表达呈负相关(P<0.05)。结论宫颈鳞癌组织中LN阳性表达率下降,CB阳性表达率升高,两者在宫颈鳞癌的浸润转移过程中起着重要作用;联合检测上述两种指标的表达情况将有助于宫颈鳞癌的早期诊断和预后判断。

Objective To explore the expressions of CB（ Cathepsin B, CB） and LN （Laminin ,LN） protein in squamous carcinoma of the cervix and its relationship with infiltration and metastasis. Methods The expressions of CB and LN protein in the squamous carcinoma of the cervix of 55 subjects were detected by immunohistochemical SP method. Results The high expressions of CB were closely correlated with metastasis, invasive depth of squamous carcinoma of the cervix （ P 〈 0.05 ） ; The down regulation of the expressions of LN were closely correlated with metastasis,invasive depth of squamous carcinoma of the cervix （ P 〈 0. 05 ） ; There was a negative correlation between the expressions of CB protein and the expressions of LN protein （ P 〈 0. 05 ）. Conclusion The expressions of CB increase , the expressions of LN decrease, they plays synergistic effect during during the process of the infiltration and metastasis; unite detection of CB and LN expressions would contribute to the early diagnosis and prognostic assessment of squamous carcinoma of the cervix.