摘要
目的评价艾司西酞普兰与帕罗西汀治疗老年抑郁症的临床疗效及安全性。方法将64例老年抑郁症患者随机分为艾司西酞普兰组32例,帕罗西汀组32例,观察6周。于治疗前和治疗1周、2周、4周、6周末采用汉密顿抑郁量表(HAMD)评定疗效,副反应量表(TESS)评定不良反应。结果艾司西酞普兰组显效率78.1%,帕罗西汀组75%,两组比较差异无显著性(P>0.05);治疗第2周末艾司西酞普兰组汉密顿抑郁量表评分(HAMD)显著低于帕罗西汀组(P<0.05)。1周、4周、6周末两组评分比较差异无显著性(P>0.05);艾司西酞普兰组不良反应发生率40.6%,帕罗西汀组43.8%,两组比较差异无显著性(P>0.05)。结论艾司西酞普兰与帕罗西汀治疗老年抑郁症具有同等疗效,但艾司西酞普兰起效较帕罗西汀快。
Objective To evaluate the clinical curative effects and safety of s - citaloparm versus paroxetine in the treatment of senile depression. Methods Total 64 patients with senile depressive disorder were randomly divided into s - citaloparm ( n = 32) and paroxetine ( n = 32) group for 6 weeks. The curative effects were assessed with the Hamilton Depression Scale(HAMD) and adverse effects with the Treatment Emergent Symptom Scale (TESS) before treatment and at the ends of the 1 st, 2nd , 4th and 6th week. Results Excellence rates were respectively 78.1% in s - citaloparm and 75% in the paroxetine group, which showed no significant difference( P 〉0.05) ;at the end of the 2st week, score of the HAMD was significantly lower in the s - citaloparm than that in the paroxetine group (P 〈 0.05). There were no significant differences at the ends of the 2nd,4th and 6th week between the 2 groups ( citaloparm and 43.8 % P 〉 0. 05) ; incidences of adverse effects were respectively 40.6% in the s - in the paroxetine group, difference was not significant ( P 〉 0. 05 ). Conclusion s -citaloparm therapeutic equivalence to paroxetine in senile depression, but takes effects faster.
出处
《医药论坛杂志》
2008年第17期25-26,共2页
Journal of Medical Forum