高频超声评价高血压患者血管内皮功能的研究

Study of endothelial function in hypertension with high-frequency ultrasonography

目的:探讨高血压对血管内皮功能的影响。方法:应用高频超声检测48例原发性高血压患者和45例血压正常的健康人在静息状态、反应性充血后以及舌下含服硝酸甘油后的肱动脉内径变化。结果:原发性高血压患者反应性充血引起肱动脉内径扩张显著低于血压正常的健康人(7.62%±5.10%)vs(14.53%±3.82%),P<0.01,舌下含服硝酸甘油引起肱动脉内径扩张差异无统计学意义(18.23%±3.20%)vs(18.87%±4.35%),P>0.05。结论:原发性高血压患者存在血管内皮依赖性舒张功能受损,高频超声可以是评价血管内皮功能的无创、简单、可靠的方法。

Objective： To investigate the relationship between hypertension and endothelial vasodilatation function.Method： High-frequency uhrasonography was applied to measure the changes of brachial artery diameter during rest, reactive hyperemia and after sublingual glyceryl trinitrate in 48 patients with mild to moderate essential hypertension and 45 normotensive healthy volunteers. Result： There was significant difference of vessel diameter changes in hypertension group and control group with reactive hyperaemia （7.62%±5.10%） vs （14.53%±3.82% ）, P 〈 0.01 ,but no significant difference after sublingual glyceryl trinitrate （18.23%±3.20% ） vs （18.87%±4.35 % ）, P 〉 0.05. Conclusion： Abnormal endothelial function exists in hypertension patients. High-frequency ultrasonography is simple, non-invasive, and accurate in evaluation endothelial function.