替莫唑胺治疗脑原发性恶性胶质瘤患者的护理

目的总结应用替莫唑胺(TMZ)治疗恶性胶质瘤患者的护理要点。方法2005年1月～2006年9月选择符合TMZ治疗适应症的脑原发性恶性胶质瘤患者,给予口服TMZ进行化疗,并配合做好护理工作。结果胶质瘤患者最短无进展生存期(PFS)Ⅲ级者9～15个月,Ⅳ级4～9个月,平均生存时间为12个月。药物治疗后有18例患者出现恶心、呕吐症状,23例患者出现口腔溃疡,18例患者出现白细胞下降,9例患者出现血小板减少症。结论做好化疗前患者心理护理、化疗知识的教育、掌握给药时间契机及密切观察患者病情及药物毒副作用,可早期预测与发现治疗后患者可能出现的并发症,从而提高TMZ治疗胶质瘤患者成功率及生活质量。

Objective To summary points for nursing patients with primordial or recurrent spongioblastoma postsurgery treated with temozolomide （TMZ）. Method 42 spongioblastoma patients were treated with oral administration of temozolomide and tender nursing care. Results The shortest PFS was 9 months for the patients with stage Ⅲ pongioblastoma postsurgery and 4 months for those at stage Ⅳ ; the longest PFS were 15 months for those at stage Ⅲ and 9 for those at stage Ⅳ, and the average surrival time was 15 months. After chemotherapy, 18 had symptoms of nausea and vomiting,23 had dental ulcer, 18 had decrease of leucocyte, and 9 thrombopenia. Conclusion Tender care of patients at chemotherapy with TMZ may improve the success rate and raise their quality of life.