摘要
目的建立高效液相色谱法测定丙二醇头孢曲嗪的有关物质。方法采用Diamonsil C18色谱柱(250×4.6mm,5μm),以0.272%磷酸二氢钾溶液-乙腈(95∶5)为流动相,流速2.0mL.min-1,检测波长270nm。结果丙二醇头孢曲嗪主峰能与相邻杂质峰较好分离。结论本法简便,准确,可对丙二醇头孢曲嗪的有关物质进行控制。
OBJECTIVE To establish an HPLC method to determine the related substances of Cefatrizine Propylene Glycolate. METHODS Diamonsil C18 column（250×4.6mm,5μm） was used. The mobile phase consisted of 0. 272% potassium dihydrogen phosphate solution -- acetonitrile （95 ： 5）. The flow rate was 2.0mL · min^-1 . The detection wavelength was 270nm. RESULTS Cefatrizine Propylene Glycolate was completely separated from impurities. CONCLUSION This method was simple and accurate for determination of related substances in Cefatrizine Propylene Glycolate.
出处
《齐鲁药事》
2008年第8期467-469,共3页
qilu pharmaceutical affairs
