血清血管内皮细胞生长因子水平评价子宫颈癌预后的价值

Prognostic value of vascular endothelial growth factor in cervical carcinoma

目的探讨宫颈癌患者的血清血管内皮生长因子(VEGF)水平与宫颈癌临床病理特征及预后的关系。方法采用酶联免疫吸附法(ELISA)检测100例宫颈癌、50例宫颈上皮内瘤变患者和30例正常健康妇女血清中VEGF水平,并进行对照分析。结果宫颈癌患者的血清VEGF水平明显高于宫颈上皮内瘤变患者和健康妇女(P<0.001),血清VEGF水平与患者的临床分期、分化程度、淋巴结转移、肿瘤大小及浸润深度显著相关(P<0.001),而与病理类型无明显的相关(P>0.05),术后血清VEGF平均含量较术前明显下降,术后复发血清VEGF含量较复发前明显升高,差异有显著性(P<0.001)。结论检测血清VEGF对判断宫颈癌患者的肿瘤负荷、疗效、复发转移、预后都有重要的参考价值。

Objective To measure the serum vascular endothelial growth factor （VEGF） in patients with cervical carcinoma and to investigate its relationship with clinico - pathological characters and prognosis. Methods Serum VEGF was measured by sandwich enzyme linked immunoabsorbent assay （ELISA） in 120 patients with cervical carcinoma, 50 with carcinoma in situ or cervical intraepithelial neoplasia and 30 healthy controls. Results The serum VEGF was significantly higher in cervical cancer than those with carcinoma in situ and cervical intraepithelial neoplasia or healthy controls （P〈0. 001）. The concentration of serum VEGF was positively correlated with clinical staging of invasive carcinoma, grade of differentiation, lymph node metastasis, tumor size and deep muscular invasion （P〈0. 001）. No significant relationship was observed between serum VEGF and the pathological types （P〉0. 05）. The postoperative VEGF was significantly lower than preoperative level. The serum VEGF increased after recurrence （P〈0. 001）. Conclusion The serum concentration of VEGF, associated with tumor burden, therapeutic effectiveness, tumor relapse and metastasis, is helpful in evaluating prognosis of cervical carcinoma.