摘要
肽酰基精氨酸脱亚氨酶（peptidylarginine deiminases,PADIs）是一种能催化蛋白质肽链中精氨酸残基脱亚氨基产生瓜氨酸残基的酶，其酶家族共有5个亚型，分别为PADI1、PADI2、PADI3、PADI4和PADI6。不同的PADIs各有不同的组织特异性。PADIl存在于子宫及皮肤表皮^[1]，PADI2广泛表达于各组织中，包括骨骼肌、子宫、脑、涎腺和胰腺等^[2]。PADI3定位于毛囊的内根鞘和外根鞘，在表皮中的表达水平很低^[3]。
出处
《中华风湿病学杂志》
CAS
CSCD
2008年第9期648-650,共3页
Chinese Journal of Rheumatology
基金
基金项目：河北省科技厅科研与发展指导计划项目（072761227）
参考文献31
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5Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidytarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet, 2003, 34: 395-402.
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6Asaga H, Nakashima K, Senshu T, et al. hnmunocytochemical localization of peptidylarginine deiminase in human eosinophils and neutrophils. J Leukoe Biol, 2001, 70: 46-51.
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8Chavanas S, Mechin MC, Takahara H, et al. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. Gene, 2004, 330: 19-27.
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同被引文献16
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1夏昭林.人类基因组计划及其进展简介[J].环境与职业医学,2001,18(5):308-309. 被引量：6
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2Vossenaar ER, Smeets TJ, Kraan MC, et al. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue.Arthritis Rheum, 2004, 50: 3485-3494.
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3Masson-Bessiere C, Sebbag M, Durieux JJ, et al. In the rheuma- toidpannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than insynovial fluid and serum. Clin Exp Immunol, 2000, 119: 544- 552.
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4Reparon-Schuijt CC, van Esch WJ, van Kooten C, et al. Secre- tion of anti citrullin-containing peptide antibody by B lympho- cytes in rheumatoid arthritis. Arthritis Rheum, 2001, 44: 41-47.
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5Fujisaki M, Sugawara K. Properties of peptidylarginine deiminase from the epidermis of newborn rats. J Biochem (Tokyo), 1981, 89 : 257-263.
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6Arita K, Hashimoto H, Shimizu T, induced activation of human PAD4 11 : 777-783. et al. Structural basis for Ca2+ Nat Struct Mol Biol, 2004, 11: 777-783.
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7Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deimi- nase 4, are associated with rheumatoid arthritis. Nat Genet, 2003, 34: 395-402.
-
8Nakashima K, Hagiwara T, Yamada M. Nuclear localization of peptidylarginine deiminase V and histone deimination in granulo- cytes. J Biol Chem, 2002, 277: 49562-49568.
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9Utz PJ, Hottelet M, Schur PH, et al. Protein phosphorylatedduring stress-induced apoptosis are common targets for autoanti- body production in patients with systemic lupus erythematosus. J Exp Med, 1997, 185: $34-854.
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10Harney SM, Meisel C, Sims AM, et al. Genetic and genomic studies of PAD14, in rheumatoid arthRitis. Rheumatology (Ox- ford), 2005, 44: 869-872.
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7史恒星,钱龙,李向培,厉小梅,汪国生,张宏.肽酰基精氨酸脱亚氨酶-4基因多态性与类风湿关节炎的相关性[J].中华风湿病学杂志,2010,14(5):336-339. 被引量：6
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