TACE联合区域灌注化疗对结肠癌术后肝转移发生率的影响

Effect of TACE Combined with Regional Antitumoral Infusion on the Incidence Hepatic Metastasis after Colon Carcinoma Resection

目的探讨结肠癌术后行肝动脉化疗栓塞(TACE)联合区域灌注化疗对肝转移及总生存率的影响。资料与方法87例结肠癌术后患者随机分成TACE联合区域灌注化疗组(A组,38例)和全身化疗组(B组,49例),比较两组患者的肝转移率及总生存率。结果A组1、2、3年的肝转移率分别为2.63%,7.89%,10.52%,明显低于B组(分别为10.20%,26.53%,36.73%),差异具有统计学意义(P<0.05)。A组1、2、3年的生存率分别为100%,92.10%,71.05%,明显高于B组(分别为95.91%,75.51%,53.06%),差异具有统计学意义(P<0.05)。结论TACE联合区域灌注化疗能有效预防结肠癌术后肝转移,显著提高总体生存率。

Objective To evaluate the effect of transcatheter arterial chemoembolization （TACE） combined with re- gional antitumoral infusion on the incidence of hepatic metastasis and overall survival rate after colon carcinoma resection. Materials and Methods 87 patients with colon carcinoma after radical surgery were randomly divided into two groups in- eluding group A consisting of 38 patients treated by TACE combined with regional antitumoral infusion, and group B consis- ting of 49 patients treated by intravenous antitumoral infusion. Incidence of hepatic metastasis and overall survival rate be- tween two groups were compared. Results 1-year, 2-year and 3-year incidence of hepatic metastasis in group A was 2.63% ,7.89% , 10.52% , respectively, and was lower than that in group B （ 10.20% , 26.53%, 36.73%, respectively） （ P 〈 O. 05 ）. 1 -year, 2 -year, and 3-year survival rate in group A 100 % , 92.10 %, 71.05 %, respectively, and was higher than that in group B （95.91%,75.51%,53.06% ,respectively） （P〈 0.05）. Conclusion TACE combined with regional antitumoral infusion could effectively prevent hepatic metastasis in patients with colon cancer after radical surgery, and im- prove survival rate.