Toll样受体与心脏疾病

Toll-like receptors and cardiac diseases

Toll样受体(Toll-like receptors,TLRs)是先天性免疫系统的重要受体,可识别不同的病原体,激活快速先天免疫反应。TLRs也可被宿主源性分子激活,不仅在免疫细胞表达,在内皮和心肌细胞也有高表达。大量研究表明,TLRs参与了心肌梗死、心力衰竭、心肌炎等心脏疾病的发生和发展,被认为是先天性免疫和心脏疾病之间的重要联系。TLRs可能是心脏疾病防治的新靶点。

Toll-like receptors （TLRs） have been identified as key receptors of the innate immune system. TLRs distinguish between different patterns of pathogens and activate a rapid innate immune response. TLRs can also be activated by host-derived molecules. In addition to being expressed in immune cells,TLRs are highly expressed in endothelium and cardiomyocytes. Lots of studies have shown that TLRs play an important role in the genesis and development of cardiac diseases, such as myocardial infarction,heart failure and myocarditis, suggesting that TLRs can be a key link between innate immunity and cardiac diseases. TLRs may be a good target for prevention and treatment of cardiac diseases.