摘要
TRP(transient receptor potential)离子通道是一类广泛存在于细胞膜上的跨膜蛋白质,可以辨别酸甜苦辣等各种味觉和温暖、冷、热等各种温度觉。TRP通道亚型TRPM8最初作为一种前列腺特异性蛋白被克隆出来,并可在热敏反应中被冷刺激和薄荷醇激活。TRPM8可以感知温度觉和痛觉,并可缓解疼痛,具有重要的研究意义。该文拟就当前TR-PM8的生物物理学、门控机制和这类TRP通道的药理及病理生理机制等进行综述。
TRP （transient receptor potential） ion channel is a kind of membrane proteins which are widespreadly present in various cells, which is used to identify various mixed flavor and warm,heat, cold, and other temperature. Originally cloned as a proatate-specific protein. TRPM8 is now best known as a coldand menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and （patho） physiology of this TRP channel .
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第9期1135-1138,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30570974)
关键词
TRPM8
温度觉
门控机制
肿瘤
TRPM8
temperature sensing
voltage-dependent gating
tumor
