氦-氧机械通气对动物急性肺损伤模型呼吸力学和氧合作用的影响

Effects of Helium-oxygen Mechanical Ventilation on Respiratory Mechanics and Oxygenation in ALI Animal Models.

目的探讨氦-氧机械通气对动物急性肺损伤模型呼吸力学和氧合作用的影响。方法应用大鼠脓毒症性急性肺损伤模型,比较空-氧混合气和氦-氧混合气(heliox)在不同呼气末正压(PEEP)下进行机械通气时呼吸力学和氧合指标的变化。结果①氦-氧机械通气不能改善动物急性肺损伤呼吸力学指标(气道峰压、平均气道压、平台压、动态顺应性、气道阻力、峰值流速等)。相反,在高PEEP水平的情况下,反而会使某些指标恶化,如动态顺应性降低(P<0.05);②氦-氧机械通气不能改善组织的氧合。结论氦-氧机械通气不能改善动物急性肺损伤的呼吸力学和氧合指标,对动物急性肺损伤没有保护作用。

Objective To investigate the effects of Helium - oxygen mechanical ventilation on respiratory mechanics and oxygenation in ALl animal models. Methods To investigate the changes of respiratory mechanics and oxygenated indexs in acute lung injury rat mod- els caused by sepsis at different PEEP by comparing air - oxygen mixture mechanical ventilation with helium - oxygen mixture mechanical ventilation. Results 1. Helium - oxygen mechanical ventilation could not improve respiratory mechanical indexs in ALl animal models （airway peak pressure,mean airway pressure, platform pressure,dynamic compliance, airway resistance,flow rate of peak value）. On the contrary,in the condition of high level of PEEP, some indexs became worse, such as depress of dynamic compliance （P 〈 0.05 ）. 2. Heli- um - oxygen mechanical ventilation was unable to improve the oxygenation of organization. Conclusion Helium - oxygen mixture mechan- ical ventilation has no influence on respiratory mechanics and oxygenated indexs in acute lung injury animal models,and has no protective effect on acute lung injury animals.