金茵颗粒剂抗豚鼠胆囊炎的实验研究

Experimental Study on Treating Cholecystitis on Guinea Pigs by Jinyin Granule.

目的研究金茵颗粒剂对豚鼠胆囊炎的治疗作用及其作用机制。方法构建豚鼠胆囊炎动物模型,然后用金茵颗粒剂进行治疗,通过豚鼠体重、胆囊重量、胆汁容积以及病理组织切片等来观察金茵颗粒剂的治疗作用,同时测定血清中的IL-1β的变化来研究其治疗胆囊炎的作用机制。结果金茵颗粒剂治疗后的豚鼠较模型组体重增加,胆囊重量减轻,胆汁容量减少,病理组织切片观察炎症反应明显减轻,血清中IL-1β含量减少。结论金茵颗粒剂对豚鼠胆囊炎有治疗作用,抗炎机制与其减少血清中IL-1β含量有关。

Objective To investigate the action and the mechanism of Jinyin granule （JYG） on choleeystitis in guinea pigs. Meth- ods Cholecystitis models of Guinea pigs were established and then randomly divided into six groups ： normal group, model group, XiaoY- anLiDan tablet （XYLDT） group, treatment groups including low, middle and high dosage groups of JYG. The Pigs were given above drugs respectively while in normal and model groups the same volume of normal saline was given. Body weight, gallbladder weight, bile a- mount, IL-11β in the serum were measured and gallbladder pathological tissue was observed by light microscopy. Results Comparing with the model group, the treatment groups had higher body weight, lower gallbladder weight, less bile amount, obviously slighter inflam- mation and less amount of IL - 1 [3 in the serum. Conclusion JYG possesses the therapeutic action to cholecystitis on guinea pigs and its mechanism is interrelated to the decreasing of IL -11β in the serum.