期刊文献+

血管内皮生长因子和抗血管内皮生长因子药物治疗进展 被引量:2

下载PDF
导出
摘要 血管内皮生长因子(VEGF)是对血管形成调节的关键分子之一,对内皮细胞特有的分裂和活化起着重要作用。VEGF由Leung等克隆出来后,迅速促进了在分子水平设计抑制相关路径来对肿瘤的治疗。针对VEGF表达的不同路径的药物相继在开发和研究中,并取得了极大的成功,但对该类药物的明确作用机制以及出现的不良反应尚待进一步研究。
出处 《安徽医药》 CAS 2008年第11期1008-1010,共3页 Anhui Medical and Pharmaceutical Journal
  • 相关文献

参考文献20

  • 1Do get cancer:few surprises in cartilage research. J Natl Cancer Inst 200 Folkman J: Tumor angiogenesis : therapeutic implications [ J ]. N Engl J Med, 1971,285 : 1182 - 6
  • 2Toi M,Bando H,Weich HA. Vascular endothelial growth factor and its relationships with endogenous inhibitors in a breast cancer micro- environment manipulated by hormonal therapy:a hypothetical consideration [ J ]. Biomed Pharmacother,2005.59 ( 2 ) : S344-7.
  • 3Leung DW,Cachianes G,Kuang WJ,et al. Vascular endothelial growth factor is asecreted artgiogenic mitogen [ J ]. Science, 1989,246:1306 - 9.
  • 4Ferrara N.Gerher HP, Le Couter J, The biology of VEGF and its receptors[ J]. Nat Med ,2003,9:669 - 76.
  • 5Kopfstein L, Veikkola T, Djonov VG, et al. Distinct roles of vascular endothelial growth factor-D in lymphangrogenesis and metastasis [ J]. Am J Patho1,2007,170(4) : 1348 -61.
  • 6Rak J, Yu JL, Klement G, et al. Oncogenes and angiogenesis : signaling three-dimensional tumor growth[ J]. J Investig Dermatol Symp, 2005,5:24 - 33.
  • 7Colla S, Tagliaferri S, Morandi F, et al. The new tumor suppressor gene inhibitor of growth family member 4 ( ING4 ) regulates the prodoction of pro-angiogenic molecules by myeloma cells and suppresses hypoxia inducible factor (HIF)-I alphal activity being involved in myeloma-induced angiogenesis [ J ]. Blood ,2007,11:346 - 8.
  • 8Neufeld G,Kessler O. Pro-angiogenic cytokines and their role in tumor angiogenesis[J]. Cancer Metastasis Rev,2006,25(3) :373 -85.
  • 9Ferrara N. Vascular endothelial growth factor : basic science and clinical progress[ J]. Endocr Rev ,2004,25 (4) :581 - 611.
  • 10Lee TK,Poon RT,Yuen AP,et al. Regulation of angiogenesis by Id- 1 through hypoxia-indueible factor-lalpha-mediated vascular endothelial growth factor up - regulation in hepatocellular carcinoma[ J]. Clin Cancer Res,2006,12 ( 23 ) :6910 - 9.

同被引文献51

引证文献2

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部