苦参素缓释纳米球的研制

Preparation of the delayed drug release nanoparticles of kurarinone

目的制备缓释苦参素纳米球。方法采用沉淀法制备苦参素-PLGA-纳米球,并用透射电镜观察其外观形态,利用HPLC测定药物含量。结果制得缓释KU-PLGA-NS,其平均包封率为79.5%,平均载药量为1.75%,平均粒径为190.5 nm。结论制备KU-PLGA-NS基本达到设计要求,该制剂有望成为一种新的药物靶向载体系统。

Aim To prepare the delayed drug release nanoparticles of kurarinone. Method Kurarinone-PLGA-nanosphere was made by precipitation method,observed by TEM,and drug contents were measured by HPLC. Results The KU-PLGA-NS has been prepared. The average rate for the encapsulation is 79.5%. The average amount of the drug is 1.75%. The average size is 190.5 nm. Conclusion KU- PLGA nanoparticles essentially meet the design requirements. The preparation is expected to become a new drug targeting vector system.