云南汉族女性痤疮与雄激素受体基因多态性的相关性研究

Microsatellite polymorphism of (CAG)n in the promoter of androgen receptor gene in Yunnan Han female acne patients

目的探讨人雄激素受体(AR)基因第一外显子CAG串联短重复序列(STR)多态性与汉族女性痤疮发生之间的关系。方法选取了86名女性患者作为研究对象,68名正常女性作为对照组,将研究对象血样提取基因组DNA,采用PCR-genescan技术研究CAGSTR的n值。结果痤疮组及对照组的CAGSTRn值范围分别为12～30和12～28,经t检验分析AR基因CAG重复片段数在对照组与各痤疮组之间分布没有差异。结论AR基因与云南汉族女性痤疮发病无明显相关性。

Objective To investigate the association between the length of the polymorphic CAG short tandem repeat（STR） at androgen receptor（AR） first exon and acne development. Methods 86 aene female patients and 68 controls were included in the study. A polymerase chain reaction （PCR） genescan technique was used to reveal the AR gene trinueleofide （CAG）n polymorphism at the first exon. T test was used for statistic analysis. Results The CAG repeat numbers for the 86 patients with acne and the controls were 12 -30 and 12 -28, respectively By using T test, we did not find significantly statistic difference between the cases and their controls. Conclusion CAG STR at the first exon of AR gene is not associated with the development and/or progression of acne in female patients.