期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

循环张力对关节软骨细胞代谢的影响 被引量：4

下载PDF
导出
摘要 关节软骨细胞时刻承受张力刺激,张力刺激的强度、频率及作用时间均会对关节软骨细胞的代谢产生影响;循环张力还可拮抗炎性因子白介素(IL)-1β、肿瘤坏死因子-α所诱导的关节软骨细胞分泌分解代谢因子。循环张力对IL-1β有拮抗作用,但在没有IL-1β存在的情况下作用并不明显,故学者们以此为突破口开展了循环张力对IL-1β抑制作用机制的研究。虽然目前对循环张力影响关节软骨细胞代谢的研究还很不充分,但足以为骨关节炎的治疗提供依据。
作者 安丙辰 张晓玲 戴尅戎
机构地区 上海交通大学附属第九人民医院骨科
出处 《国际骨科学杂志》 2008年第5期289-290,303,共3页 International Journal of Orthopaedics
基金 国家自然科学基金(30600628)
关键词 循环张力 软骨细胞 代谢 炎性因子
分类号 R684.3 [医药卫生—骨科学] R274 [医药卫生—中医骨伤科学]
  • 相关文献

参考文献18

  • 1Smith RI., Carter DR, Schurmhn DJ. Clin Orthop, 2001.427(Suppl):S89-S95.
  • 2李世民,陆芸.胡永成译.关节器官:关节软骨[A].见:王学谦.娄思权,侯筱魁.等译.骨关节炎:诊断与治疗[M].第1版.天津:天津科技翻译出版公司.2005:50-52.
  • 3O'Connor JJ,Johnson IA.Transmission of rapidly applied load through articular cartilage:the mechanics of osteoarthrosis[A].In:Turner-Smith AR ed.Micromovement in Orthopaedies[M].Oxford:Clarenton. 1993:244-268.
  • 4Kelly PA, O'Connor JJ. Transmission of rapidly applied loads through articular cartilage. Part 1:Uncracked cartilage. Proc Inst Mech Eng, 19961 210(1):27-37.
  • 5Toyoda T, Saito S, Inokuchi S, et al. The effects of tensile load on the metabo lism of cultured chondrocytes. Clin Orthop. 1999:359:221-228.
  • 6Matsukawa M, Fukuda K. Yamasaki K. et al. Enhancement of nitric oxide and proteoglycan synthesis due to cyclic tensile strain loaded on chondrocytes attached to fibronecrilt Inflamm Res. 2004 53(6):239-244.
  • 7Fukuda K, Asada S, Kumano F, et al. Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity. J Lab Clin Med. 1997. 130(2): 209-215.
  • 8Connelly JT, Vanderploeg EJ, Levenston ME. The influence of cyclic tension anolitude on chondrocyte matrix synthesis; experimental and finite element analyses. Biorheology, 2004:41(3-4):377-387.
  • 9Fujisawa T, Hattori T, Takahashi K. et al. Cyclic mechanical stress induces ex tracellular matrix degradation in cultured chondrocytes via gene expression of rrmtrix metalloproteinases and interleukin-1. J Piochem. 1999; 125(5):966-975.
  • 10Huang J, Ballou LR, Hasty Y,KA. Cyclic equibiaxial tensile strain induces both anabolic and catabolic responses in articular chondrocytes. Gene, 2007. 404( 1 2):101-109.

同被引文献81

  • 1顾延,戴克戎,裘世静,戴闽.应力降低导致关节软骨退变机理的形态学研究[J].中华骨科杂志,1995,15(9):631-633. 被引量：44
  • 2中华人民共和国科学技术部.关于善待实验动物的指导性意见.2006.09-30
  • 3Smith RL,Carter DR,Schurman DJ.Pressure and shear differentially alter human articular chondrocyte metabolism:a review.Clin Orthop Relat Res,2004(427 Suppl):S89-95.
  • 4Fujisawa T,Hattori T,Takahashi K,et al.Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.J Biochem (Tokyo),1999,125(5):966-975.
  • 5Huang J,Ballou LR,Hasty KA.Cyclic equibiaxial tensile strain induces both anabolic and catabolic responses in articular chondrocytes.Gene,2007,404(1-2):101-109.
  • 6Sun H,Wu C,Dai K,et al.Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics.Biomaterials,2006,27(33):5651-5657.
  • 7Stoop R,Albrecht D,Gaissmaier C,et al.Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients.Arthritis Res Ther,2007,9(3):R60.
  • 8Kelly PA,O'Connor JJ.Transmission of rapidly applied loads through articular cartilage.Part Ⅰ:Uncracked cartilage.Proc Inst Mech Eng,1996,210(1):27-37.
  • 9Connelly JT,Vanderploeg EJ,Levenston ME.The influence of cyclic tension ampulitude on chondrocyte matrix synthesis:experimental and finite element analyses.Biorheology,2004,41(3-4):377-387.
  • 10Becerra J,Andrades JA.Articular cartilage:structure and regeneration.Tissue Eng Part B Rev.in press.

引证文献4

二级引证文献18

国际骨科学杂志
2008年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部