期刊文献+

蛋白聚糖酶与骨关节炎 被引量:3

下载PDF
导出
摘要 蛋白聚糖酶介导的蛋白聚糖降解是骨关节炎(OA)软骨早期病变的关键之一。蛋白聚糖酶属带有凝血酶敏感蛋白样模体的裂解素和金属蛋白酶家族成员,在OA软骨蛋白聚糖降解过程中起着重要作用,可能成为OA治疗靶点。该文就蛋白聚糖酶、蛋白聚糖结构与功能,蛋白聚糖酶主要作用位点、在OA中的调控、特异性抑制剂、与OA病程中软骨蛋白聚糖降解的关系等作一综述。
作者 黄恺 吴立东
出处 《国际骨科学杂志》 2008年第5期327-329,共3页 International Journal of Orthopaedics
  • 相关文献

参考文献41

  • 1Hardingham T. Extracellular matrix and pathogenic mechanisms in osteoarthritis Curr Rheumatol Rep. 2008; 10(1):3036.
  • 2Watanabe H. Aggrecan and its chondroitin sulfate in cartilage. Seikagaku, 2008; 80(1):28-32.
  • 3Sandy JD, Neame PJ, Boynton RE, et al. Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain. J Biol Chem, 1991 ; 266(14) :8683-8685.
  • 4Blaney-David,mn EN, Vitters EL, van Lent PI,. et al. Elevated extracellular nkatrix production and degradation upon bone morphogenetic protein-2 (BMP 9) stimulation point toward a role for BMP2 in cartilage repair and remodeling. Arthritis Res fher. 2007. 9(5):RI02.
  • 5Gendron C, Kashiwagi M, l.im NH, et al. Proteolytic activitics of human .ADAMTS-5: comparative studies with ADAMTS-4. J Biol Chem, 2007; 282(25): 18294-18306.
  • 6Zeng W. Corcoran C, Collins-Rade I.,A. et al. Glycosaminoglycarrbincling prcr perties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMIS-5, -9, -16 and -18. Biochim Biophys.Acta. 2006. 1760(3):517-524.
  • 7Stevens M., Wheeler CA, Tannenbaum SR. et al. Nitric oxide enhances aggrecan degradation by aggrecana~ in reaponse to TNF-alpha but not IL-lbeta treat ment at a post-transcriptional level in bovine cartilage explants. Osteoarthritis Cartilage, 2008. 16(4):489-497.
  • 8Karsdal MA, Surfer EU. Wulf H. et al. Induction of increased cAMP levds in art cular chondrocytes blocks mAtrix metalloprote nase-mediated cartilage degradation, but not aggrecanasesn-mediated cartilage degradation. Arthritis Rheum, 2007; 56(5):1549-1558.
  • 9Shao X, Hunter CJ. Developing an alginate/chitosan hybrid fiber .scaffold for annulus fihrosus cells. J Biomed Mater Res A, 2007; 82(3):701-710.
  • 10Laroazares M. Obaya AJ, Moncada-Pazos A. et al. The ADAMTS12 metalloproteinase exhibits anti-t urrlorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci. 2007; 120(Pt 20):3544-3552.

同被引文献32

  • 1史海水,宋利,姜玲玲.蛋白激酶D:一个新的蛋白激酶家族[J].生命的化学,2007,27(3):229-231. 被引量:2
  • 2Buckwalter JA, Nankin HJ,Qodzinslty AJ. Articular cartilage and osteoarthritis[J].Instr Course Lect, 2005, 54:465-480.
  • 3Poole AR,Kobayashi M,Yasuda T, et al. Type Ⅱ collagen degradation and its regulation in articular cartilage in osteoarthritis [J]. Ann Rheum Dis, 2002, 61(Suppl 2) :ii78-ii81.
  • 4Nagase H, Kashiwagi M. Aggrecanases and cartilage matrix degradation [J].Arthritis Res Ther, 2003 , 5(2):94-103.
  • 5Cbnaghan PG. Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies[J]. Nat Rev Rheumatol, 2013, 9(2):68-70.
  • 6van der Kraan PM,Blaney-Davidson EN, van den Berg WB. Bone morphogenetic protans and articular cartilage: to serve and protect or a vrolf in sheep dothing's?[J]. Osteoarthritis Cartilage,2010, 18(6) :735-741.
  • 7Hayashi M,Mjneta T, Takahashi T, et al. Intra-articular injections of bone morphogenetic protein-7 retard progresaon of existing cartilage degeneration[J]. J Qrthop Res,2010, 28(11):1502-1506.
  • 8Hayashi M, Muneta T, Ju YJ, et al. Weekly intra-articular injections of bone rnorphcgenetic protein-7 inhibits osteoarthritis progresaon[J]. Arthritis Res Ther,2008,10(5):R118.
  • 9Fosang AJ,Little CH Drug insight: aggrecanases as therapeutic targets for osteoarthritis[J]. Nat Qin Pract Rheumatol, 2008,4(8):420-427.
  • 10Reboul P,Pelletier JP, Tardif G, et al. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis[J]. J Qin Invest, 1996, 97(9) :2011-2019.

引证文献3

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部