脂肪组织和脂肪细胞因子的研究进展

Advance on adipose tissue and adipokines

脂肪组织是一个活跃的内分泌和旁分泌器官,分泌许多细胞因子和生物活性因子。脂肪组织的分泌功能存在节律性,全身各脂肪库脂肪因子的表达和分泌具有特异性,提示其复杂的生物学功能。脂肪组织是促炎症反应介质的丰富来源,这些介质参与炎症、凝血和纤溶反应,可直接引起血管损伤、胰岛素抵抗和动脉粥样硬化;脂肪细胞因子是肥胖和代谢综合征的分子联系。

Adipose tissue is an active endocrine and paracrine organ that releases a large number of cytokines and bioactive mediators. Adipose tissue exist a rhythm of secretion; the expression and secretion are specific in each discontinuous fat depot all over the body; And these has been further indicated that the biological function of adipose tissue is complicate. Furthermore it has been considered lately that adipose tissue is an abundant origin of proinflammatory media that influence not only body weight homeostasis but also inflammation, coagulation, fibrinolysis, that may directly cause the injury of blood vessels, insulin resistance and atherosclerosis. Adipokines have been known as the molecule link between obesity and metabolism syndrome. Thus adipose tissue of endocrinology has already become a new field of endocrinology.