摘要
血管紧张素受体拮抗剂（ARB）是一类作用于受体水平的抗高血压药物，可通过扩张外周血管提高组织血流灌注、增强葡萄糖向外周胰岛素敏感组织的转运和摄取、促进脂肪细胞分化、抑制脂肪组织炎性反应、减轻游离脂肪酸毒性作用、减少交感神经兴奋，拈抗氧化应激反应和调节基因表达。因而具有增强胰岛素敏感性，改善胰岛素抵抗的作用，为2型糖尿病合并高血压的治疗开辟了更广阔的前景。
Angiotensin receptor blocker（ARB） is acting as an antihypertensive drug at the receptor level. Because of its important roles in improving insulin resistance through dilating the blood vessels via increasing the peripheral tissue perfusion, enhancing the glucose transport and uptake by tissue sensitive to insulin, promoting preadipocyte differentiation,inhibiting the inflammation of the adipose tissue, decreasing the toxicity of free fatty acid, blocking the oxidative stress reaction and modulating the gene expression of angiotensin Ⅱ , ARB has opened up broad prospects for the treatment of type 2 diabetes mellitus with hypertension.
出处
《国际内分泌代谢杂志》
2008年第5期303-305,共3页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（30671095）
关键词
血管紧张素受体拈抗剂
胰岛素抵抗
炎性因子
2型糖尿病
Angiotensin receptor blocker
Insulin resistance
Inflammatory cytokines
Type 2 diabetes mellitus
