改良扩张方法对兔静脉移植物再狭窄的影响

Effects of Improved Distension on Vein Graft Restenosis

目的观察不同扩张方法对兔静脉移植物通畅率的影响。方法健康纯种新西兰兔30只,按扩张液(空白对照、罂粟碱和罂粟碱+维拉帕米)随机分为A、B、C组,每组10只。各组分别以50、50、30 mm Hg扩张2 min,保存30 min。部分血管测定内膜厚度及截面积、管腔面积和直径,测定内皮细胞功能。扩张后行颈外静脉颈总动脉移植,28 d后再次检测上述指标。结果移植28 d后各组内膜均有增厚,内膜截面积增加,但C组明显低于A、B组;同样,各组管腔面积、直径以及内皮细胞功能均有下降,但C组高于A、B组(P<0.01)。结论改良的扩张方法可增加静脉移植物通畅率。

Objective To evaluate the effects of improved distension on vein graft rest enosis. Methods Thirty rabbits were divided into 3 groups randomly according to different distension solution（control, Papaverine, Papaverine ＋ Verapamil）. All external jugular veins harvested were distended under different pressure and different distension solution respectively. The thickness and section area of endomembrane,the area and diameter of vein graft lumina and endothelial cell function were measured. Results Twenty eight days after transplantation,the thickness and section area of endomembrane increased in each group, and the area and diameter of vein graft lumina and endothelial cell function decreased. However in group C,all the indexes were much better than the other two. Conclusion Improved distension can improve the restenosis of vein graft.