多囊卵巢综合征青年患者血清脂联素水平与胰岛素抵抗关系的研究

Study on the Relationship of Serum Adiponectin,Resistin and Insulin Resistance of Young Polycystic Ovary Syndrome Patients

目的探讨多囊卵巢综合征青年患者血清脂联素水平与胰岛素抵抗的关系。方法病例组为38例青年多囊卵巢综合征患者，对照组为27例同龄健康女性，两组根据体质指数分为肥胖组（体质质数≥25kg／m^2）和非肥胖组（体质指数（25kg／m^2）。在月经第3～5天晨（多囊卵巢综合征闭经者B超检查无优势卵泡当天）留空腹血清。采用酶联免疫吸附法测定血清脂联素水平，葡萄糖氧化酶法测定血糖水平，化学发光法测定胰岛素水平，根据后两者计算胰岛素敏感指数。结果①多囊卵巢综合征组与对照组空腹血糖水平比较，差异无统计学意义（P〉0．05）；②多囊卵巢综合征组空腹胰岛素水平明显高于对照组（P〈0．01）；③多囊卵巢综合征组血清脂联素水平和胰岛素敏感指数明显低于对照组（P〈0．01）；④多囊卵巢综合征组肥胖、非肥胖者及对照组肥胖、非肥胖者脂联素水平和胰岛素敏感指数依次递增，血胰岛素浓度依次递减，组间比较，差异有统计学意义（P〈0．01）。结论多囊卵巢综合征青年患者血清脂联素水平降低，以肥胖者降低更明显，且可能与胰岛素敏感性及胰岛素抵抗相关。

Objective To study the relationship of serum adiponectin（APN） and insulin resistance of young polycystie ovary syndrome （PCOS） patients. Methods Thirty eight young PCOS patients and 27 healthy young females were assigned as experiment group and control group. Each group was divided into obesity group[body mass index（BMI） ≥25 kg/ m^2 ]and non-obesity group（BMI〈25 kg/m^2）. SerumAPN levels of the four groups were detected by Enzyme Linked Immuno Sorbent Assay （ELISA）. Blood glucose concentration was detected by glucose oxidase method, and insulin concentration was detected by chemiluminescence method, and the Insulin Sensitivity Indexes（ISI） were calculated. Results ①The concentration of fasting blood glucose of experiment group was equal to the control group （P〉0.05）.②The concentration of fasting insulin of experiment group was statistically higher than the control group（P〈0.01）. ③The serum APN concentration and ISI of experiment group were statistically lower than that of control group（P〈0.01）. ④The serum APN concentrations and ISI were statistically increased progressively, and the insulin concentrations were statistically decreased progressively（P〈0.01） in obesity group of experiment group, non-obesity group of experiment group, obesity group of control group and non obesity group of control group successively. Conclusion Serum APN level of experiment group is lower than control group,and the tendency is more obvious in obesity group, which may be related to insulin sensitivity and insulin resistance.