血清CA125水平测定对结核性胸膜炎诊断及疗效的临床意义

Level of the serum CA125 for the diagnosis and therapeutic effect of tuberculous pleurisy

目的探讨结核性胸膜炎患者治疗前后血清糖类抗原125(CA125)水平的变化及临床意义。方法采用电化学发光法检测40例健康体检者(对照组)以及46例结核性胸膜炎患者(结核性胸膜炎组)抗结核治疗前及治疗1个月和3个月后血清CA125的水平。结果结核性胸膜炎组患者血清CA125水平显著高于对照组,阳性率为92.3%,差异有显著性(P<0.01);结核性胸膜炎组患者抗结核治疗1个月后血清CA125水平显著低于治疗前(P<0.01);治疗3个月后血清CA125水平显著低于治疗1个月后(P<0.01)和治疗前(P<0.01)。结论临床上可用血清CA125测定辅助诊断结核性胸膜炎以及观察疗效。

[Objective] To study the change of serum carbo antigen 125 （CA125） in patients with tuberculous pleurisy after and before treatment, and to explor its clinic significance. [Methods] The levels of serum CA125 in 40 healthy controls （control group） and 46 tuberculous pleurisy patients （tuberculous pleurisy group） were measured by eleetrochemilurnineseenee method. Tuberculous pleurisy patients were treated for 1 month and 3 months, and the serum levels of CA125 were also measured. [Results] The serum levels of CA125 were significantly higher in tu- berculous pleurisy group than those in control group. The positive rate was 92.3%, P 〈0.01, after treated for 1 month. The serum levels of CA125 were significantly lower in tuberculous pleurisy group than pretherapy （P 〈0.01）. After treated for 3 month, in tuberculous pleurisy group serum CA125 were significantly lower than treated for 1 month （P 〈0.01） and pretherapy （P 〈0.01）. [Conclusion] In clinical, serum CA125 may be used for diagnosis of tu- berculous pleurisy and observed efficacy.