绵阳市73例格林-巴利综合征的临床和流行病学分析

Clinical and epidemiological analysis of 73 Guillain-barre syndrome cases in Mianyang

目的了解绵阳市格林-巴利综合征(GBS)病例的临床和流行病学特征。方法对绵阳市1997～2006年AFP监测系统报告73例格林-巴利综合征(GBS)病例进行流行病学分析。结果绵阳市15岁以下儿童GBS的平均发病率为1.79/10万,以散发为主,男女性别之比为1.15∶1.00;5～10个月报告65例,占全年总病例数的89.04%;发病高峰月份为7月,出现23例,有夏秋季高发的特点。结论该地GBS发病率较预期高,应加强对当地儿童特别是小于5岁年龄组的AFP监测,重症病例的预防和治疗,最大限度地降低发病率和致残率。

[Objective]The aim of this study was to investigate the clinical and epidemiological features of Guil- lain-Barre syndrome in Mianyang city. [Methods] Epidemiological data of 73 cases with Guillain-Barre syndrome in Mianyang which reported by AFP monitoring system between 1997 and 2006 were analyzed. [Results] The aver- age annual incidence rate of GBS was 1.79 per 100,000 among the children under 15 years in Mianyang city. The disease was mainly sporadic, the mMe/female ratio was 1.15：1.00. 65 cases were reported during May to October which accounted for 89.04% of the total eases and 23 cases occurred in July which was the incidence peak month. The highest proportion of the syndrome was observed in summer and autumn. [ Conclusion] The results indicated that an unexpected high incidence of GuiUain-Barre syndrome has occurred in the region. Effective measures should be taken to monitor AFP levels for children especially to fewer than 5 years old and to prevent and therapy severe cases in order to reduce the ratio of incidence and mutilation of GBS utmost.