藻酸双酯钠对糖尿病大鼠降脂作用的研究

The Lowered Lipids Efficiency of Lovastatin in Fat-fed Streptozotocin-Treated Rats

目的观察藻酸双酯钠(PSS)对糖尿病大鼠脂代谢的影响,探讨其可能的作用机理。方法制备食饵性高脂糖尿病大鼠模型,洛伐他汀(Lov)为阳性对照药物,观察藻酸双酯钠对糖尿病大鼠血脂的影响。结果与DM组相比,PSS及Lov均可明显降低糖尿病伴高血脂大鼠TG、TC、LDL-C水平,升高HDL-C水平。结论PSS可明显降低糖尿病伴高血脂大鼠血脂,且PSS有一定的剂量依赖性。

Objective To investigate the lowered lipid efficiency of Lovastatin （Lov） on glycometabolism in fat-fed strepto- zotocin-treated diabetic rats （Fat-fed/STZ rats）.nethods The rat model of diabetes was established. Male Wistar rats adapt- ed surrounding for a week,then they randomly divided into normal control group（NC group）and model groups.NC rats were fed conventional chow for seven weeks and then injected with vehicle of 0.1mol/L citric acid buffer（pH 4.5）; while model rats were fed high-fat diet （30% of calories as fat） for seven weeks and then injected with streptozotocin （STZ,20mg·kg^-1, via the caudal vein once）.After two weeks of STZ treatment,all of groups were administered daily by garage for a months. NC group and MC group were administered with 0.1mol/L citric acid buffer.Then the effects of PSS on lipids concentrations in fat-fed strepotozotocin-treated diabetic rats was studied.Results All Fat-fed/STZ groups had higher glucose con- centrations to N C group,and significantly higher triglyceride （TG）,total cholesterin（TC）,low-density lipoprotein （LDL-C）, high-density lipoprotein （HDL-C）.PSS（administered for a month） reduced TG （P〈0.01）,TC（P〈0.01）,LDL-C（P〈0.01） and increased HDL-C（P〈0.05） in PSS groups compared with DC group.Conclnsions PSS can correct the hyperlipidemia in fat-fed, streptozotocin-induced diabetic rats.