利奈唑胺治疗革兰阳性球菌感染的定位

Orientation of Linezolid in Treatment of Gram-positive cocci Infections

革兰阳性球菌是社区和医院感染的重要病原菌,其中较为常见的有金黄色葡萄球菌、肠球菌、链球菌等。近几十年来,随着抗生素的广泛应用,细菌耐药情况日趋严重。大量文献报道显示,利奈唑胺在治疗耐药革兰阳性球菌感染方面比糖肽类、β-内酰胺类抗生素更有效。如何对利奈唑胺进行正确的临床定位,使之既能保证疗效,又不至于因滥用而导致其临床寿命缩短,对充分发挥该药的优良抗菌作用意义重大。

Gram-positive cocci, including S. aureus, Enterococci and Streptococci, are important vital pathogens in community and hospital infections. Since antibiotics have been widely used in the past decades, the drug resistance problem has increasingly become a severe problem that harasses medical workers. Recently, a number of literatures have showed that linezolid is more effective than glycopeptides or β -lactams in the treatment of drug resistant gram-positive bacterial infections. Thus, the proper use of linezolid should be stressed in order to keep its effect and avoid drug resistance occurring in a short time due to drug abuse.