产超广谱β-内酰胺酶大肠埃希菌耐药性分析

Analysis of antibiotic resistance of extended-spectrum β-lactamases-producing Escherichia coli strains

目的：了解产超广谱β-内酰胺酶（ESBLs）大肠埃希菌的耐药性,为临床合理选用抗生素提供依据。方法：2005年9月~2006年6月,收集临床分离产ESBLs大肠埃希菌63株,采用琼脂平皿稀释法进行MIC测定。结果：产ESBLs大肠埃希菌对碳青霉烯类和哌拉西林/他唑巴坦普遍敏感,对哌拉西林和喹诺酮类耐药率分别为98.41%和90.48%,对头孢吡肟、头孢哌酮/舒巴坦、头孢他啶、头孢西丁、头孢噻肟和头孢曲松耐药率依次为34.92%、36.51%、44.45%、55.56%、82.54%和84.13%。结论：我院产ESBLs大肠埃希菌耐药明显。

Objective ： To study the resistance of the extended-spectrum β-lactamases （ ESBLs ） -producing Escherichia coli （ E. coli） strains and to provide basis for clinical therapy, nethods：Agar dilution method was used to determine MICs of 13 antibiotics against 63 strains of ESBLs-producing E. coli which were collected between October 2005 and June 2006 in our hospital. Results： ESBLsproducing E. coli was generally sensitive to carbopenems and piperacillin/tazobatan, while most strains were highly resistant to piperacillin and quinolones. The rate of resistance to cefepime, ceforazone/sulbactam, ceftazidime, cefoxitin, ceftaxime and ceftriaxone were 34.92% ,36.51%, 44.45 %, 55.56% , 82.54% and 84. 13%, respectively. Conclusions ： ESBLs-producing E. coil strains are highly resistant to antibiotics in our hospital.