动脉化疗栓塞对膀胱癌组织中Ki-67表达的影响

Influence of arterial chemoembolization on expression of Ki-67 in bladder cancer

目的探讨术前动脉化疗栓塞对膀胱癌组织中核增殖相关抗原（Ki-67）表达的影响。方法对30例动脉化疗栓塞前后的膀胱癌组织，应用免疫组化方法测定尉-67的表达，并分析Ki-67与膀胱癌病理分级和临床分期的关系。结果动脉化疗栓塞前后Ki-67阳性和强阳性表达率分别为70.00％、26．67％，差异有统计学意义（P〈0．01）。30例患者平均随访24．6个月，复发率为16．67％。Ki-67阳性表达及动脉化疗栓塞前后降低幅度与膀胱癌的病理分级、临床分期和患者术后复发率关系密切。结论Ki-67的表达可作为膀胱癌预后评估的指标。

Objective To investigate the influence of preoperative arterial chemoembohzation on expression of Ki-67,and clinical significance in bladder cancer. Methods Before and after chemoembolization of therapy , the expression of Ki-67 in 30 patients of bladder cancer tissue were examined by immunohistochemical staining. The relation of its expression to the pathological grade and clinical stage was evaluated clinically. Results Positive rate of Ki-67 expression in the bladder cancer tissue was 70.00% and 26.67% respectively. There was significant difference between the before and after therapy （P 〈 0.01 ）. Follow-up for mean 24.6 months recurrence rate in 30 cases was 16.67%. The expression of Ki-67 correlated to the pathological grade, clinical stage and patient recurrence rates of bladder cancer. Conclusions Preoperative arterial chemoembolization can reduce the expression of Ki-67 ,adjust malignancy of bladder cancer, could downgrade and downstage the tumors, and cut down the postoperative metastasis, improve survival rate and reduce recurrence rate. Both of the Ki-67 labeling index are predictive factor for recurrence of superficial bladder cancer.