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神经退行性疾病相关蛋白的翻译后修饰 被引量：2

Post-translational modifications of neurodegenerative disease proteins
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摘要 特定靶蛋白的翻译后修饰对其执行细胞功能有重要作用,是细胞对生长、分化和应激等信号刺激所产生的调节功能的一种反应.翻译后修饰包括磷酸化修饰、乙酰化、甲基化、泛素化、类泛素化等不同的修饰.在神经退行性疾病的研究中,翻译后修饰对疾病的发生和病理影响日益受到人们的重视,我们对磷酸化、泛素化和类泛素化(SUMO化)修饰与神经退行疾病的关系及本实验室的工作进行介绍. Post-translational modifications of target proteins are important for these proteins to execute their cellular functions and enable ceils to respond to stimuli. There are phosphorylation, acetylation, methylation, ubiquitination, SUMOylation and other modifications to modify target proteins. In the research of neurodegenerative diseases, post translational modifications participate in the process and pathogenesis of the diseases attracting increasing attention. In this review, we discuss the relationship between neurodegenerative diseases and phosphorylation, ubiquitination or SUMOylation and introduce our laboratory＇s work.
作者 费尔康 范骏 王洪枫 章涛 王光辉
机构地区 中国科学技术大学生命科学学院分子神经病理学实验室
出处 《中国科学技术大学学报》 CAS CSCD 北大核心 2008年第8期978-985,共8页 JUSTC
基金 国家自然科学基金(30770664)资助
关键词 神经退行性疾病 蛋白质翻译后修饰 neurodegenerative diseases post-translational modifications
分类号 Q593.2 [生物学—生物化学]
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参考文献43

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共引文献7

同被引文献28

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中国科学技术大学学报
2008年 第8期

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