阿托伐他汀对糖尿病肾病患者血TGF-β_1表达的影响

Effect of Simvastatin on the Expression of Serum TGF-β_1 in Patients with Diabetic Nephropathy

目的旨在研究阿托伐他汀降脂以外的作用——阿托伐他汀对糖尿病肾病患者血TGF-β_1表达的影响。方法选取血糖控制达标的糖尿病(CKD2—3期)患者60例,随机分成3组,1组为对照组,未使用阿托伐他汀;2、3组为治疗组分别给与阿托伐他汀20 mg/d、40 mg/d。治疗组给予治疗16周,分别检测对照组、治疗组治疗前、治疗后6、12、16周血TGF-β_1、β_2-微球蛋白、24 h尿蛋白、血肌酐、血尿酸、血脂。结果治疗组治疗前与对照组比较差异无显著性(P>0.05);治疗组经阿托伐他汀治疗6、12、16周后,血TGF-β_1、尿蛋白明显下降,12周和16周与治疗前水平比较均差异有显著性(P<0.05),16周与6、12周比较差异亦有显著性(P<0.05),但6周与治疗前比较则差异无显著性(P>0.05);20 mg/d组与40mg/d组相比差异有显著性(P<0.05)。结论阿托伐他汀能减轻糖尿病肾病的蛋白尿,该作用可能通过降脂以外的降低TGF-β_1的作用实现。

Objective To investigate the effect of simvastatin on the patients with diabetic nephropathy （DN）--Effect of simvastatin on the expression of serum TGF-β1 in patients with diabetic nephropathy . Methods 60 case of patients with DN （2,3） were randomly divided into 3 groups , the I group was not used simvastatin, the 2and 3group was used simvastatin 20mg/1,40mg/1.2,3groups cured 16weeks, β2 - MG,24h - urinary albumin;the serum level of Scr,UA,TG,TC and TGF -β1 were detected at baseline and 6 week later, 12week late,16week late. Results There were no different between 1 and 2,3 before cured. 6 week later, 12week late,16week late the serum level of TGF-β1,24h- urinary albumin were declined, 12week late, 16week late the serum level of TGF-β1,24h -urinary albumin had significance to before cured （p 〈0.05） ,6 week later had no significance to before cured （p 〉 0.05 ） , the 2 group and 3 group had significance（p 〈 0.05 ）. Conclusion Simvastatin can prevent the development of diabetic nephropathy through inhibiting the expression of TGF -β1.