肠道微生态在炎症性肠病发病中的作用

Role of Intestinal Microecology in the Pathogenesis of Inflammatory Bowel Disease

炎症性肠病(IBD)是一类病因不明的肠道炎性疾病,主要包括溃疡性结肠炎和克罗恩病,其发病机制尚未清楚,可能涉及遗传、免疫和环境因素,其中肠道菌群所构成的肠道微生态可能扮演重要角色,已日益引起重视。本文通过对该领域的新进展作一概述,旨在加深对肠道微生态与IBD关系的认识以及探讨治疗IBD的新策略。

Inflammatory bowel disease （IBD）,which includes ulcerative colitis and Crohn’s disease,is a chronic inflammatory disorder of gastrointestinal tract with unknown etiology which may be referred to genetics,immunology and environmental factors. Accumulated evidences suggest that intestinal microecology comprised by gut flora plays an important role in the development of IBD,which increasingly evokes the interests of many researchers. The present article introduced the latest studies of microecology in IBD for further understanding the relationship between IBD and intestinal microecology and to explore the new therapeutic strategy for IBD.