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脂联素及T-钙黏蛋白与大鼠糖尿病心肌病的关系 被引量:4

The correlation of adiponectin and T-cadherin with STZ-induce drat diabetic cardiomyopathy
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摘要 观察糖尿病(DM)大鼠心肌细胞形态学变化,测定血清脂联素(APN)及受体T-钙黏蛋白(T-cad)在心肌的表达水平。DM大鼠心肌细胞超微结构出现符合糖尿病心肌病改变,血清APN及T-cad的表达随着病变发展而升高。血清APN及T-cad的表达均随时间延长增多,从而发挥其保护作用。 The pathological changes in myocardial cell of diabetic rats were consistent with diabetic eardiomyopathy. The levels of adiponectin and the expression of T-eadherin in diabetic group were increased gradually, and higher than in normal control group.
作者 田腊梅 李兴
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2008年第8期505-506,共2页 Chinese Journal of Diabetes
关键词 脂联素 T-钙黏蛋白 糖尿病心肌病变 Adiponectin T-cadherin Diabetiecardiomyopathy
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参考文献5

  • 1Randeva HS, Manu V, Bee KT, et al. Raised plasma adiponectin levels on type 1 diabetic pregnancies. Clinical Endocrinology, 2006,65:17- 21.
  • 2Yang WS, Lee WJ, Funabeshi T, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein adiponectin. Clin Endoerinol Metab, 2001,86 : 3815-3819.
  • 3Hug C, Wang J, Ahmad NS, et al. T-cadherin is a receptor for hexamerie and high molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sei USA, 2004,101 : 10308-10313.
  • 4Motoshoma H, Wu X, Mahadev K, et al. Adiponectin suppresses proliferation a superoxide generation and enhances eNOS activity in endothelial cells treated oxidized LDL. Biochem Biophys Res Commun, 2004,315 : 264-271.
  • 5Joshi MB, Philippova M, Ivanov D, et al. T eadherin protects endo thelial cells from oxidative stress induced apoptosis. FASEB, 2005,10:1096- 1119.

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