T2DM酮症患者血清脂联素水平变化及其与血脂的关系

The decreased serum adiponectin level and its correlation with serum lipids during ketosis period in type 2 diabetes

目的探讨2型糖尿病(T2DM)酮症患者血清脂联素(APN)水平的变化,以及其与血脂等因素的相关性。方法选择T2DM酮症患者(酮症组)52例,无酮症患者(非酮症组)58例;另选健康个体54例为正常对照(NC)组。分别测身高、体重、空腹血清APN、血糖、HbA1c、血脂。结果两组患者血清APN水平明显低于NC组(P<0.01)。酮症组APN水平明显低于非酮症组(P<0.01)。血清APN水平与HbA1c、TC、TG呈负相关,与HDL-C呈正相关,酮症组患者酮症纠正后APN水平与非酮症患者相比,差异无统计学意义。结论糖尿病酮症期间APN水平明显降低,酮症纠正后恢复。

Objective To investigate the change of serum adiponectin level and the correlation of serum adiponectin with serum lipids. Methods 110 T2DM patients were devided into diabetic ketosis group, and non-diabetic ketosis group. 54 healthy persons were chosen as normal control group. Patients＇ height, weight, BMI were measured respectively and fasting blood samples were taken for detecting adiponeetin, glucose,HbA1c and lipids. Results Serum adiponeetin was significantly lower in T2DM patients than in normal control group （P〈0.01）. Serum adiponeetin level was lower in diabetic ketosis patients than in non-diabetic ketosis patients（P〈0. 01） and negatively correlated with HbA1c, TC, TG and positively correlated with HDL-C during ketosis period. Conclusion Adiponectin level becomes lower after diabetic ketosis and returns to the pre-ketosis level after ketosis disappars.