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非小细胞肺癌组织中hnRNP B_1和CD44的联合表达及其与预后的关系 被引量：3

Co-expression and Prognostic Significance of hnRNP B_1 and CD44 in Non-small Cell Lung Cancers
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摘要 目的研究核内不均一核糖核蛋白B1(hnRNP B1)和CD44在非小细胞肺癌组织中的联合表达及其与预后的关系。方法应用免疫组织化学的方法检测88例非小细胞肺癌组织中hnRNP B1和CD44表达,分析hnRNP B1和CD44的联合表达与肺癌预后的关系。结果非小细胞肺癌组织中hnRNP B1和CD44的高表达率分别为68.18%和52.27%。hnRNP B1高表达且CD44低表达组,平均生存时间最高(59.607±4.092)月;hnRNP B1低表达且CD44高表达组,平均生存时间最低(21.357±3.545)月,差异具有统计学意义(P<0.05)。结论hnRNP B1与CD44联合检测对判断非小细胞肺癌的预后有一定临床意义。 Objective To study the co-expression and prognostic signlfieance of hnRNP B1 and CD44 in non-small cell lung cancers （NSCLC）. Methods The co-expressions of CD44 and hnRNP B1 in the tissues from 88 cases of NSCLC were measured by immunohistochemistry. The relationship between the expressions and the prognosis of NSCLC was analysed. Results The NSCLC had a high expression of hnRNP B1（68.18%） and CD44 （52.27%）. The cells had the longest average life （（59. 607±4. 092） months] in the conditions of high expressed hnRNP Bl and low expressed CD44, and shortest average llfe （（21. 357±3. 545） months] in the conditions of low expressed hnRNP B1 and high expressed CD44. Conclusion Combined detection of hnRNP ]31 and CD44 can help forecast the prognosis of NSCLC.
作者 邓太兵 李为民 莫显明 刘伦旭 刘丹 蒲蓉 陈勃江 徐炼
机构地区 四川大学华西医院呼吸内科 四川大学华西医院生物治疗国家重点实验室 四川大学华西医院胸外科 四川大学华西第二医院病理科
出处 《四川大学学报（医学版）》 CAS CSCD 北大核心 2008年第5期819-822,共4页 Journal of Sichuan University(Medical Sciences)
基金 教育部博士点基金(批准号20050610056)资助
关键词 CD44 核内不均一核糖核蛋白B1 非小细胞肺癌 CD44 Heterogeneous nuclear ribonucleoprotein B1 Non-small cell lung cancer
分类号 R734.2 [医药卫生—肿瘤]
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参考文献9

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同被引文献32

  • 1李为民,陈文彬,徐丹,朱辉,魏大鹏,周清华.纤维支气管镜刷检细胞核内不均一核糖核蛋白B_1染色诊断肺癌价值的研究[J].中国呼吸与危重监护杂志,2004,3(4):229-232. 被引量：14
  • 2潘铁成,郑智,李军,汤应雄,潘友民,魏翔,陈涛,张霓.肺鳞癌、腺癌肿瘤大小与淋巴结转移关系的临床研究[J].中国肺癌杂志,2006,9(3):267-269. 被引量：13
  • 3汤旭东,万瑛,陈婷,熊震,陈陵,余松涛,罗元辉,杨仕明.小鼠肝素酶H-2K^b限制性CTL表位预测及其MHC-I亲和力分析[J].重庆医学,2007,36(9):820-822. 被引量：6
  • 4Sueoka E, Sueoka N, Goto Y, et al. Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia[J].Cancer Res,2001,61 (5) : 1896-1902.
  • 5Tockman MS, Mulshine JL, Piantadosi S, et al. Pro spective detection of preclinical lung cancer: results from two studies of HnRNP expression[J]. Clin Cancer Res, 1997, 3(12) :2237- 2246.
  • 6Tominaga M, Sueoka N, Irie K, et al. Detection and discrimination of preneoplastic and early stages of lung adenocarcinoma using hnRNP B1 combined with the cell cycle-related markers p16, cyclin D1, and Ki-67 [J].Lung Cancer, 2003,40 ( 1 ) : 45-53.
  • 7Wu SL, Sato M, Endo C, et al. hnRNP B1 protein may be a possible prognostic factor in squamous cell carcinoma of the lung[J].Lung Cancer,2003,41(2) : 179-186.
  • 8Pino I, Pio R, Toledo G, et al. Altered patterns of expression of members of the heterogeneous nuclear ribonucleop rotein (hnRNP) family in lung cancer[J]. Lung Cancer, 2003,41 (2): 131-143.
  • 9Tockman MS, Mulshine JL, Piantadosi S, et al. Prospective detection ofpreclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression[J].Clin Cancer Res,1997,3(12) :2237-2246.
  • 10Fielding P, Turnbull L, Prime W, et al. Heterogeneous nuclear ribonucleoprotein A2/B1 up-regulation in bronchial lavage specimens:A clinicalm arkerof early lung cancer detection [J]. Clin Cancer Res, 1999,5 (12) :4048-4052.

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四川大学学报（医学版）
2008年 第5期

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