2007年88医院医院感染病原菌分布及耐药性分析

Drug resistance and its distribution of nosocomial infection pathogens of No. 88 hospital in 2007

目的调查医院感染病原菌的分布及耐药趋势,为指导临床用药及控制医院感染提供依据。方法对医院2007-01～2007-12培养分离出的1106株病原菌,采用自动微生物分析仪ATBExpression及配套试剂进行细菌鉴定和药敏试验。结果发现革兰阳性球菌288株(26.0%),耐甲氧西林株分别占金黄色葡萄球菌和凝固酶阴性葡萄球菌的72%和89.4%,未发现耐万古霉素菌株;革兰阴性杆菌680株(61.5%),以大肠埃希菌、铜绿假单胞菌和肺炎克雷伯菌为主;革兰阴性杆菌对碳青酶烯类的亚胺培南耐药率最低,其次为阿米卡星、哌拉西林/他唑巴坦。真菌137株(12.4%),念珠菌为主。结论医院感染的耐药问题严重,临床应根据病情及时做病原菌检测,结合药敏试验结果,正确合理使用抗菌药物。

Objective To investigate the tendency of bacterial distribution and resistance of hospital infections, and to provide the reference for the clinical treatment and infection control in hospital. Methods A total of 1 106 strains of NI pathogens from Jan ：2007 to Dec2007 were identified by ATB expression, and bacterial susceptibility tests were performed on strains using Kirby-Bauer method. Results Among them Gram-positive cocci were 288 strains （26.0%）, Meticillin resistant strains of staphylococcus aureus and coagulase negative staphylococcus （CNS） accounted for 72% and 89.4%, respectively. No Vancomycin resistant S. aureus were isolated. There were 680 strains of Gram-negative bacilli （61.5%）, the most common pathogens of them were Escherichia cOli, Pseudomonas aeruginosa, Klebsiella pneunwniae. The highest susceptibility to Gram-negative bacilli was imipenem of carbapenem, then amikacin, piperacillin/tazobactam. Fungus were 137 strains （12.4%）, the most of them was Candida. Conclusion Drug resistance of the nosocomial infection bacteria is a serious problem. The clinically selected anti-bacterial drugs should be based on the bacterial culture and drug susceptibility test.