丹参注射液对COPD患者肺功能及血清高迁移率族蛋白B1的影响被引量：1

Effect of complex salvia miltiorrhiza on the changes of pulmonary function and HMGB1 in the serum of COPD patients

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摘要目的:观察丹参注射液对慢性阻塞性肺疾病患者(chronic obstructive pulmonary disease,COPD)肺功能、血流变学、血清高迁移率族蛋白B1(high mobility group protein box-1,HMGB1)及肿瘤坏死因子α(tumor necrosis factor α,TNF-α)水平的影响。方法:将74例COPD患者随机分为常规治疗组(常规组)34例和丹参注射液辅助治疗组(丹参组)40例,常规组给予COPD常规治疗,丹参组在此基础上给予丹参注射液20ml加入5%葡萄糖液250ml中静脉点滴,每天1次,共用14天。另选17例健康志愿者为正常组。检测各组患者肺功能、血流变学、血清TNF-α水平的变化,WB法检测血清HMGB1水平改变。结果:丹参组治疗后患者肺功能显著改善,FEV1及FEV1%显著高于常规组,mPAP显著下降并低于常规组,血流变学主要指标均显著改善。丹参组治疗后血清HMGB1和TNF-α水平较常规组显著降低,HMGB1和FEV1及FEV1%显著负相关,和TNF-α水平显著正相关。结论:丹参注射液辅助治疗可显著改善COPD患者肺功能、血流变学状况及血清TNF-α水平,其机制可能与其降低COPD患者血清HMGB1含量有关。 Objectlve：To investigate the effect of complex salvia miltiorrhiza on the changes of pulmonary function,hemorheology, HMGB1 and TNF-α in the serum of COPD patients. Methods：74 COPD patients were divided into 2 groups：34 eases in the control group and 40 cases in the salvia miltiorrhiza group.Patients in the control group received normal treatment.Patients in the salvia miltiorrhiza group were injected with 20 ml complex salvia miltiorrhiza everyday for 14 days.17 healthy people were included as the normal group.The pulmonary function,hemorheology and the level of HMGB1 and TNF-α in the serum in each group were detected. Results：The FEV1 and FEV1% in the salvia miltiorrhiza group were significant by higher than those in the control group.The level of mPAP in the salvia miltiorrhiza group decreased and was lower than that in the control group.The end of hemorheology detection became better.The content of HMGB1 in the salvia miltiorrhiza group decreased significantly.The level of TNF-α was lower than that in the control group.The content of HMGB1 was negative correlated with FEV1 and FEV1% ,and positive correlated with TNF-α. Conclusion： Complex salvia miltiorrhiza can improve the pulmonary function,hemorheology and decrease the level of TNF-α in the serum of COPD patients ,which had relationship with the changes of HMGB1 in the serum.

作者赵勇

机构地区遂宁市人民医院呼吸内科

出处《现代医药卫生》 2008年第19期2891-2893,共3页 Journal of Modern Medicine & Health

关键词慢性阻塞性肺疾病丹参注射液高迁移率族蛋白B1 肿瘤坏死因子Α COPD Complex salvia miltiorrhiza HGMB 1 TNF-α

分类号 R25 [医药卫生—中医内科学]

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