桂西地区幽门螺杆菌对克拉霉素耐药的调查

Survey of the drug resistance of helicobacter pylori to clarith romycin in Guixi area

目的:了解桂西地区幽门螺杆菌(HP)对克拉霉素的耐药情况。方法:对2006年6月～2007年12月行胃镜检查,并经尿素酶试验初步确认HP感染的患者,取其胃黏膜标本进行微需氧培养,经生化、涂片检查鉴定为典型的HP,经转代选择其中生长发育良好的菌株126株,应用K-B法药敏试验测定其对克拉霉素的敏感性。结果:126株HP菌株中,对克拉霉素耐药的有28株,耐药率为22.2%(28/126)。结论:桂西地区HP菌株对克拉霉素耐药率略高,有必要定期检测或调查HP对抗生素的敏感性,以监测治疗的效果,提高根除HP的疗效。

Objective：To investigate the antibiotic resistance of Helicobacter pylori isolated from Patients to clarithromycin in area. Methods：Gastric mueosa biopsy specimens were taken from patients under going gastroscopy due to dyspeptic symptoms in affiliated hospital of You jiang medical college for nationalities from June 2006 to December 2007.All patients were diagnosed as having Helicobacter pylori infection by urease test.One hundred twenty-six strains of Helicobacter pylori were isolated from these patients by mieroaerobic culture.In vitro susceptibilities of clarithromycin were detemrined by K-B test on these 126 Helicobacter pylori strains. Results ：The resistance rate was 22.2%（28/126） for clarithromyein.Conclusion ：The resistanee rates was high than other aera.Then, there was a need to investigate the antibiotic resistance of Helieobacter pylori isolated from patients in local areas regularly,so as to monitor the effect of treat strategy for Helicobacter pylori infection and to enhance the efficacy of Helicobacter pylori eradication therapy.