β-淀粉样蛋白前体蛋白胞内结构域(AICD)与阿尔茨海默病

The progress in researching APP intracellular domain (AICD)

阿尔茨海默病的(Alzheimer's disease,AD)一个重要的病理学特征之一是脑内出现β-淀粉样蛋白(β-amyloid,Aβ)组成的淀粉样斑。β-淀粉样蛋白前体蛋白(β-amyloid precursor protein,APP)经β-分泌酶和γ-分泌酶依次水解后产生Aβ和APP胞内结构域(APPintracellular do-main,AICD)。现在已经知道Aβ在AD的发病机制中起着关键作用,但是关于AICD的生理及病理功能还不清楚。近年来研究发现AICD可以与细胞内多种蛋白相互作用,而且AICD在基因转录、细胞凋亡,突触可塑性,神经发生以及APP的加工和运输过程中均有调节功能。本文针对AICD的生理及病理功能进行探讨。

one of the most important features of Alzheimer＇s disease is the appearance of abeta plaque in the brain. APP is processed by β secretase and γ, secretase in a row and producing AICD as well as abeta. It＇s now known that abeta played an extremely important role in the onset of AD, but less is known about AICD. In recent years, studies had implied that AICD can interact with a large amount of cellular protein and thus had a regulation role in the gene transcription, cell apoptosis, synaptic plasticity and neuron genesis aspects as well as the field of pocessing and transport of APP. The purpose of this review is to discussing the physiological and pathological functions of AICD.