粒细胞集落刺激因子治疗局灶性脑缺血性损伤

Granulocyte Colony Stimulating Factor for Focal Cerebral Ischemic Injury

粒细胞集落刺激因子（G—CSF）可将造血干细胞（HSC）从骨髓中动员到外周血循环中，刺激HSC和骨髓基质细胞（MSC）向脑缺血病灶归巢，促使HSC和MSC与缺血半暗带细胞相互作用，促进神经营养因子产生。G—CSF还具有抗神经元凋亡作用，驱动神经发生。利用G—CSF动员自体HSC和MsC治疗局灶性缺血性脑损伤，可缩小脑梗死体积，促进神经功能恢复。

Granulocyte colony stimulating factor （G-CSF） can mobilize hemopoietic stem cells （HSCs） from bone marrow to peripheral circulation, stimulating HSCs and marrow stromal cells （MSCs） homing to the lesion of cerebral ischemia, contributing to the interactions of HSCs and MSCs with the cells in ischemic penumbra, and promoting the generation of neurotrophic factors. G-CSF also has antiapoptotic effect on neurons and drives neurogenesis. Mobilizing autologous HSCs and MSCs using G-CSF for the treatment of local cerebral ischemic injury may reduce the volume of cerebral infarction, and improve neurological functional recovery.