异硫氰酸盐的抗肿瘤机制和研究进展(英文)

Anticancer Mechanisms and Researches of Isothiocyanates

异硫氰酸盐和它的人工衍生物抗肿瘤作用非常广泛,本文就其抗肿瘤机制和研究进展进行综述。异硫氰酸盐类是通过修饰药物代谢酶、影响细胞周期和细胞分化、诱导凋亡、抑制增殖和抗血管生成、抗氧化、抗炎症、提高机体免疫力、抗激素作用、抑制环氧化酶-2活性、协同抗癌药物和耐药逆转等联合机制抗肿瘤的。异硫氰酸盐类作用于多阶段致癌的不同时期,它们是理想的防、抗癌剂,这些得到了许多相关的临床研究证实。所以,异硫氰酸盐类是多靶点的化学防癌剂,它们是很有前景的化学防、抗癌的药物。

The anticancer effects of Isothiocyanates and their synthetic derivates （ITCs） are very extensive. The anticancer mechanisms and the researches of ITCs are reviewed in this paper. The mechanisms may be combination and modification of drug-metabolizing enzymes, influence on the cell cycle and cell differentiation, induction of apoptosis, suppression of proliferation and angiogenesis, anti-oxidant, anti-inflammatory, immune-enhancing, anti-hormone effects, inhibition activity of Cycloxygenase-2, synergy on anticancer drugs and reverse effect on drugs resistant. ITCs are ideal chemoprevention and anticancer agents since they can affect different phases of multistage carcinogenesis. Many related clinical researches have confirmed that ITCs have the functions of anticancer and chemoprevention. So ITCs are not only multitarget chemoprevention agents, but also quite promising chemoprevention and anticancer agents.