电针对佐剂性关节炎大鼠炎症局部κ阿片受体mRNA表达的影响被引量：2

Effects of Electro-acupuncture on Kappa Opioid Receptor in Inflammatory Location of Adjuvant Arthritis Rats

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摘要目的:从阿片受体角度观察电针(EA)对佐剂性关节炎(AA)大鼠产生镇痛的外周机制。方法:以Fre-und’s完全佐剂造成AA大鼠模型,在EA治疗后观测大鼠痛阈、炎症局部κ阿片受体(KOR)mRNA的表达。结果:EA治疗后,大鼠的痛阈提高,炎症局部KOR mRNA的表达增强。结论:EA对AA大鼠有明显镇痛效应,且镇痛效应的产生与大鼠炎症局部的KOR mRNA表达增强有关。 Objective： To observe the effects of electro - acupuncture （ EA ） on the opioid receptors gene expression in the inflammatory location of adjuvant arthritis （AA） rats, and to seek the peripheral mechanism of EA analgesia. Methods： Freand＇ s adjuvant was adopted to induce AA model. The pain threshold and mRNA expression of KOR were observed after EA treatment. Results ： Pain threshold was raised, and KOR mRNA expression were increased after EA analgesia in AA rats, Conclusion： Electro- acupuncture has an obvious effect of analgesia on AA rats. The mechanism is related to the increase of KOR mRNA expression.

作者盛佑祥赵仓焕

机构地区深圳市第六人民医院康复医学科暨南大学附属第一医院

出处《四川中医》北大核心 2008年第9期10-11,共2页 Journal of Sichuan of Traditional Chinese Medicine

基金广东省中医药局科研基金资助项目(97246)

关键词电针佐剂性关节炎阿片受体 κ阿片受体(KOR) 基因表达 electro- acupuncture adjuvant arthritis Kappa Opioid receptor （KOR） gene expression

分类号 R285.5 [医药卫生—中药学]

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参考文献8

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