摘要
目的考察超细粉体技术对小儿腹泻外敷凝胶中丁香酚透皮吸收的影响。方法以丁香酚单位面积累积渗透量为指标,采用Franz扩散池分别对药材普通粉和超细粉制备的两种小儿腹泻外敷凝胶进行小鼠离体皮肤体外渗透实验。结果丁香酚在两种凝胶中均以零级释放过程透过皮肤,其透皮吸收速率分别为7.89±1.80、10.72±2.32μg/(cm2.h),二者具有显著性差异(P<0.05)。结论超细粉体技术可以加快凝胶中有效成分的吸收,提高生物利用度。
Objective To investigate effect of ultra-powder technology on transdermal absorption of eugenol from Xiaoér Fuxie Waifu gel. Methods The release test of two kinds of Xiaoér Fuxie Waifu gel was assayed with Franz diffusion cell by the index of cumulative releasing of eugenol in unit area in vitro. Results The percutaneous absorption process of eugenol in two kinds of gels were conformed to zero-order releasing model, and the transdermal rates were 7.89±1.80 and 10.72±2.32μg/（cm^2·h） respectively. There was significant difference between two kinds of gel（ P 〈 0.05 ）. Conclusion The technology of superfine could favor transdermal absorption of eugenol and improve bioavailability.
出处
《现代中药研究与实践》
CAS
2008年第4期51-53,共3页
Research and Practice on Chinese Medicines
基金
南京医科大学科技发展基金项目(NY03034)
