热休克蛋白90与白血病
Heat shock protein 90 and leukemia
摘要
热休克蛋白90(HSP90)是细胞中的一类分子伴侣蛋白,与作用蛋白结合后能维持蛋白质稳定,保证作用蛋白功能的正常发挥。HSP90通过与多种作用蛋白结合,影响细胞的生长、发育、分化及基因转录等,在白血病的形成和发展中起着特有的作用。该文介绍HSP90的结构、功能及与白血病的关系,并综述HSP90抑制剂治疗白血病的研究进展。
出处
《国际儿科学杂志》
2008年第5期419-422,共4页
International Journal of Pediatrics
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