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胆汁酸对线粒体的毒性作用 被引量:8

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出处 《肝脏》 2008年第4期343-346,共4页 Chinese Hepatology
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  • 1Pauli-Magnus C, Meier PJ. Hepatocellular transporters and cholestasis. J Clin Gastroenterol, 2005. 39:S103-110.
  • 2Palmeira CM, Rolo AP. Mitochondrially mediated toxicity of bile acids. Toxicology. 2004,203 : 1 - 15.
  • 3Gazawi H,Ljubuneic P, Cogan U, et al. The effects of bile acids on ? -adrenoreceptors, fluidity, and the extent of lipid peroxidation in rat cardiac membranes. Bioehem Pharmacol,2002,59 : 1623- 1628.
  • 4Beuers U. Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol, 2006,3:318-328.
  • 5Yerushalmi B, Dahl R, Devereaux MW, et al. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology, 2001, 33:616-626.
  • 6Bernstein C, Payne CM, Bernstein H, et al. Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate. Pharmacology, 2002,65 : 2-9.
  • 7Rolo AP, Palmeira CM, Wallace KB. Mitochondrially mediated synergistic cell killing by bile acids. Biochim Biophys Acta, 2003, 1637:127-132.
  • 8Gumpricht E, Devereaux MW, Dahl RH, et al. Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis. Toxicol Appl Pharmacol,2000,164:102-111.
  • 9Soden JS, Devereaux MW, Haas JE, et al. Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis. Hepatology, 2007,46 : 485-495.
  • 10Oh SH, Yun KJ, Nan JX, et al. Changes in expression and immu- noloealization of protein assoeiated with toxic bile salts-induced ap optosis in rat hepatocytes. Arch Toxicol, 2003,77 : 110-115.

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