我国葡萄膜炎研究现状、问题及今后研究方向

Uveitis reserch in China： problems and future directions

我国葡萄膜炎研究的现状是眼科医生对葡萄膜炎的认识水平普遍有所提高；糖皮质激素使用逐渐趋于合理化；其他免疫抑制剂的应用逐渐得到重视；抗生素使用逐渐减少；葡萄膜炎研究的国际影响力扩大。但存在研究工作的地区差异较大，并发症治疗中误区较多，糖皮质激素玻璃体内注射的合理评价有待重视等问题。Behqet病和伏格特-小柳-原田综合征是我国常见的葡萄膜炎类型和重要的致盲类型，梅毒性葡萄膜炎、艾滋病、真菌性眼内炎、伪装综合征等原来少见的一些葡萄膜炎类型近年逐渐增多。开展多中心合作研究，探讨Behcet病和伏格特-小柳-原田综合征不同治疗方案的治疗效果，优化出最佳的治疗方案；重视近年来逐渐增多的葡萄膜炎类型的临床特征；探讨免疫耐受的诱导对葡萄膜炎的预防和治疗作用等是今后值得重视的研究课题。

The knowledge of uveitis of Chinese eye doctors has been improved in general. While the usage of glucocortieoid agents was more reasonable, other non-eortieoid immunosuppressant get more attention recently. The usage of antibiotics also has being reduced gradually. The international impact of our uveitis research has been enhanced. However there are still some problems, such as big difference between different regions of uveitis research, still many misunderstandings on the treatment of uveitis complications, and the reasonable evaluation of intravitreal injection with glucoeorticoid needs emphasis. In China Behcet＇s disease and Vogt-Koyangi Harada syndrome are the most common uveitis subtypes which can lead to blindness,but some rare subtypes of uveitis are also increasing such as syphilitic uveitis, acquired immune deficiency syndrome（AIDS）,mycotic endophthalmitis and masquerade syndrome. In the future we need cooperative studies between multicenters to investigate the effectiveness of different treatment strategies for Behcet＇s disease and Vogt Koyangi-Harada syndrome, and to optimizing the best therapeutic schedule. We also need to pay more attentions to the clinical features of those uveitis subtypes which increased recently;and to investigate the prevention and therapeutic effect of induction of immune tolerance to uveitis.