伏格特-小柳-原田综合征并发脉络膜皱褶的临床分析

Clinical analysis on choroidal folds in Vogt-Koyanagi-Harada disease

目的 观察伏格特-小柳-原田（VKH）综合征并发脉络膜皱褶的临床特征。方法回顾分析112例临床确诊的VKH综合征患者中16例并发脉络膜皱褶的患者临床资料。所有患者均行眼底彩色照相及荧光素眼底血管造影（FFA）检查，其中8例患者同时行吲哚青绿血管造影（ICGA）检查，7例患者行光相干断层扫描（OCT）检查。结果112例患者中，16例并发脉络膜皱褶，占14．3％。FFA检查显示，视盘周围呈现10～15条呈放射状行走的弱荧光带（脉络膜细皱褶），形态及走行状似视网膜大血管；ICGA检查显示，后期脉络膜皱褶的槽底呈强荧光条；OCT检查显示，Bruch膜和视网膜色素上皮反光带呈波浪状皱褶。结论VKH综合征并发的脉络膜皱褶以视盘周围呈放射状行走的细皱褶为特征，是VKH综合征一个并不少见的眼底征象。

Objective To observe the clinical features of choroidal folds in Vogt Koyanagi Harada disease. Methods The clinical data of 112 patients with choroidal folds in Vogt-Koyanagi Harada disease were retrospectively analyzed. All patients were examined by fundus color photography and fundus fluorescein angiography （FFA）. 8 patients underwent indocyanine green angiography （ICGA） and 7 patients received optical coherence tumography （OCT） meanwhile. Results Of the 112 patients, 16 patients （14.3%） had choroidal folds, on FFA, there are 10 to 15 hypofluorescenct bands radiating from the optic disk which were similar to the large retinal vessels in shape and number（choroidal fine folds）. On ICGA the ehoroidal folds showed obvious hyperfluorescence at the late stage. On OCT the reflective bands of Brueh membrane and retinal pigment epithelium （RPE） showed the wavy folds. Conclusions Choroidal folds in Vogt-Koyanagi Harada disease are characterized by fine folds radiating from the optic disk which is not uncommon in Vogt-Koyanagi-Harada disease.