广州市1978至2006年登革热流行病学特征分析

The analysis of the epidemiologic features of dengue fever from 1978 to 2006 in Guangzhou, China

目的对广州市登革热发病和流行特征进行分析，进而提出相应的防控策略。方法对广州市1978至2006午法定传染病年报、疫情监测、实验室监测、历年登革热防挎工作总结以及相关的调查报告、疫情简报和阶段性汇报材料等数据进行收集、提取和分析。结果仝市各区、县级市均有登革热病例报告，累计报告登革热病例数13301例，死亡12例。先后有13个年份出现不同规模大小流行，有8年无病例报告．其他年份有散发或输入病例报告。登革病毒血清型的4个型别曾在广州市流行，除1991年出现登革Ⅰ型和登革Ⅳ型两种病毒血清型的交替流行外，其他年份为一种血清型；5至12月份为流行期，8至9月份为发病高峰，疫情发生与控制程度有关；临床类型以典型登革热为主。病死率较低；性别、年龄和不同人群发病风险差异无统计学意义。结论广州市登革热流行持续时间K、波及范围较广；疫情多由输人性病例引起。

Objective To analyze the epidemiologie features of dengue fever in Guangzhou from 1978 to 2006 and to provide the information for constituting the prevention and control strategy of dengue fever in the future. Methods The data from situation surveillance system, lab surveillance system, field investigation report and briefing were gathered and analyzed. Results From 1978 to 2006, the total reported cases of dengue fever in Guangzhou were 13 301 with 12 deaths. During this period, prevalence of dengue fever was reported in 13 years while no cases reported in the other eight years. Four types of virus had even prevailed in the history in Guangzhou. The epidemic period was from May to December with the peak from August to September. The shape of epidemic curve was associated with the control of the outbreak. The clinic manifestations of most dengue fever cases were typical and tbe mortality rate was very low. There was no significance between different genders, different age group and different populations. Conelusions Outbreaks of dengue fever in Guangzhou usually last for long time and influence a relatively wide area. Most cases are imported from outside.