CK34βE12和Cath-D在乳腺癌中的表达及意义

The Expression of Cytokeratin34βE12 and Cathepsin-D in Breast Carcinoma and its Significance

[目的]探讨CK34βE12和Cath-D在乳腺癌组织中的表达水平和临床意义。[方法]用免疫组化法对189例乳腺癌组织和66例癌旁组织中CK34βE12和Cath-D的表达水平进行测定。[结果]CK34βE12的表达与乳腺癌患者的肿瘤大小、组织学分级、病理类型、临床分期、腋淋巴结阳性转移等指标均有显著性相关(P<0.05)。Cath-D的表达与患者的月经状态、雌激素表达、组织学分级、病理类型、临床分期、腋淋巴结阳性转移等指标有显著性相关(P<0.05)。CK34βE12和Cath-D在乳腺癌中的表达无相关性。[结论]CK34βE12或Cath-D可以用来判断乳腺癌的恶性程度和预后。

[Purpose] To investigate the expression of CK34betaE12 and cathepsin-D in breast cancer and its clinical significance. [Mcthodsl The expression of CK34betaE12 and cathepsin-D was detected in cancer tissues from 189 cases with breast cancer and in cancer adjacent tissues from 66 cases immunohistochemically. [Results] The expression of CK34betaE12 in breast cancer tissues correlated to tumor size, pathologic type, grade, TNM staging, and positive axillary node （P〈0.05）. The expression of cathepsin-D in breast cancer tissues correlated to menstrual status, estrogen receptor, pathologic type, grade, TNM staging and positive axillary node（P〈0.05）. No correlation was found between CK34betaE12 expression and cathepsin-D expression. [Conclusion] CK34betaE12 and cathepsin-D might be helpful for evaluating the aggression and prognosis in breast cancer.