潍坊高新区儿童接种甲肝疫苗后人群抗体水平检测

Evaluation on antibody levels of population after children hare been vaccinated against viral hepatitis A.in Gaoxin District of Weifang City

目的了解儿童接种甲肝疫苗后人群甲肝总抗体水平。方法按不同年龄分成7组,分别于1996年疫苗接种前及2005年儿童接种疫苗后9年,检测正常人群720名和803名甲肝总抗体。血清检测法ELISA。结果疫苗接种后人群总抗体阳性率有显著的提高。青少年及儿童(18岁以下)抗体阳性率有接种前的29.84%提高到接种后的64.15%(P<0.01)。成人组(25～35)抗体阳性率从78.9%到84.5%,没有显著差别(P>0.05),但未见有下降趋势。结论儿童接种甲肝疫苗显著地提高了人群抗体水平,同时没有发现疫苗接种后易感人群的后移。

Objective To understaid the effect on HAV antibody levels of population in children vaccinated against viral hepatitis A. Methods Two groups of children from Weifang city of Shandong Province were divided into seven subgroups according to ages respectively. 720 subiects （ group1 ） were detected of anti - HAV - IgG levels in 1996, and 803 ones （group2） were detected in 2005 after nine years of mass vaccination . ELISA method was used in serum test . Results Anti - HAV - IgG rate of whole population increased significantly. The positive rate in adolescents and children （ 〈 18 years old） increased from 29.84% to 64. 15% （ P 〈0. 01 ） ; and in adults （25 to 35 years old） from 78.9% to 84. 5% with no statistical significance （ P 〉 0. 05） . Conclusion HAV antibody levels of population in children significandy increase after vaccinating against viral hepatitis A, and no retrocession in age groups of susceptibility is found.